The Sixth World Congress on Psychiatric Genetics


Chairman of the Congress:

Peter Propping, M.D.
Institute of Human Genetics
University of Bonn
Wilhelmstr. 31
D-53111 Bonn, Germany
Phone #49 - 228 - 287 2346
Fax #49 - 228 - 287 2380

International Program Committee:

Peter Propping, M.D. (Chairman)
Bonn,Germany
William Byerley, M.D.
Salt Lake City, USA
Tim Crow, M.D., Ph.D.
Oxford, UK
Lynn DeLisi, M.D.
Stony Brook, USA
Elliot S. Gershon, M.D.
Chicago, USA
Bernard Lerer, M.D.
Jerusalem, Israel
Wolfgang Maier, M.D.
Bonn, Germany
Peter McGuffin, M.D., Ph.D. (President, ISPG)
Cardiff, UK
Steve Moldin, Ph.D.
Bethesda, USA
Markus M. Nöthen, M.D.
Bonn, Germany
John Nurnberger, M.D., Ph.D.
Indianapolis, USA
Michael Owen, M.D., Ph. D.
Cardiff, UK
Theodore Reich, M.D. (Vice President, ISPG)
St. Louis, USA
Christine van Broeckhoven, Ph.D.
Antwerp, Belgium
Dieter Wildenauer, Ph. D.
Bonn, Germany

Local Organizing Committee:

Max P. Baur, Ph.D.
Sven Cichon, Ph.D.
Wolfgang Maier, M.D.
Markus M. Nöthen, M.D.
Marcella Rietschel, M.D.
Sibylle Schwab, Ph.D.
Dieter Wildenauer, Ph.D.



Prof. Propping, Germany's leading eugenicist


Statement

by the Bundesverband Psychiatrie-Erfahrener (BPE) e.V.
(National Association of Psychiatric Users and Survivors)
on the 6th World Congress on Psychiatric Genetics

  1. The Nazi "Euthanasia" program began with psychiatric genetics. Today we see the same developments!
  2. We strongly doubt that this research serves the interests of the patients.
  3. We reject the bio-medical model of mental illness.
  4. We regard the genetic-psychiatric research as being part of the Human Genome Project.
  5. We wish to point out that the Human Genome Project is also used to develop biological weapons, the aim being to build weapons for selective extermination of population groups with certain genes.
  6. We feel threatened by this, just as we do by any future pre-natal eugenic diagnosis and gene manipulation. How long will it be before the so-called "schizophrenia gene carrier" is aborted and embryos are genetically changed!
  7. We consider psychiatric genetics to be abysmal, absurd and evil! Gene technology, selection and eradication is apparently having a renaissance.
  8. Congresses such as these must be prevented in the future!


The general meeting of the Bundesverband
Psychiatrie-Erfahrener e.V.* September 26, 1998



*The BPE is the organized representative for the interests of psychiatric patients in Germany!




Protest Flyer distributed at the congress



General Information


Congress Venue

The congress will take place in the district of Poppelsdorf. The area can be reached by bus lines no. 620, 624, 625, 626, 627 leaving from the central bus/main railway station. From the pedestrian zone and the main university building the walking distance along the Poppelsdorfer Allee is 10-1 5 min. The lecture halls are in the Institutes of Anatomy, Geography, Physics, and the Poppelsdorf Castle (see map on back cover). The Registration Desk of the congress is located in the foyer of the Institute of Anatomy (B on map). A message board is located in the registration area. For the comfort of all, smoking is not permitted inside any congress area.

Sessions

Sessions will take place in five lecture halls. The posters will be exhibited in two rooms at the Castle. Please refer to the schedule at-a-glance and the area map. Posters should be set up on Tuesday at 14:00-18:00. The poster format is 1 x 1 m. All posters will be exhibited for the duration of the congress. Authors should be at their posters at the respective times; please refer to the program schedule. Please be sure to wear your badge for admittance into the sessions.
Equipment for slide check will be available in the registration area.

Luggage Room

A room will be available where luggage is guarded from 8:00 to 19:00. However, the organizer cannot take any responsibility. Optional Events
Optional events include (please refer also to the map on the back cover):
- Welcome Reception at the Aula of the University (A on map, Tuesday, 19:00-21:00), free of charge.
- Reception at the Federal Art Museum with the opportunity to visit the exhibition "Gene Worlds" (Thursday, 20:00-22:30), free of charge.

- Boat trip along the Rhine with dinner buffet (Friday, 18:00-22:00). The boat leaves at Alter Zoll (7 on map). The price for this dinner event is DM 48.

- Bus visit to the State Mental Hospital at Hadamar (Saturday, 16:00-22:00, limited number of participants), free of charge. The bus leaves in front of the Institute of Geography (D on map). Hadamar was one of the euthanasia hospitals where more than 10 000 mentally ill patients were murdered in Nazi Germany. Administered by the central organization T4 the Patients were systematically collected in the psychiatric hospitals all over Germany. The remains of the extermination machinery - now a memorial - will be presented in the context of historic documents of the eugenic ideas.

Post-congress excursion of one day to the nearby city of Cologne. The price for the guided tour and Transport to and from Cologne is DM 45 (lunch not included). Please contact the registration desk.

Refreshments and Lunch

During the breaks refreshments will be available free of charge in the registration area and in the foyer of lecture hall 1. During the poster sessions refreshments will be available free of charge at the castle. At lunchtime a light meal will be offered in the foyer of lecture hall 1. On a separate flier that will be distributed at the registration information on nearby restaurants is given.

Additional Meetings

Wednesday, October 7,12:00-14:00, Hall 5
Discussion: „The problem of overlapping recruitment of families"
Chair: Wolfgang Maier, Bonn

Thursday, October 8, 13:30-15:30, Hall 5
Task Force: „Standardization of diagnostic criteria in linkage studies"
Chair: Peter McGuffin, Cardiff

Saturday, October 10, 15:30-18:30, Hall 5
Meeting of ADHD researchers
Chair: Stephen V. Faraone, Boston


Program Schedule


Wednesday, October 7, 1998

09:00-9:30
Plenary Session 1 - Hall 3:
Opening

09:00 Welcome and Introduction
Peter Propping (Bonn, Germany)

09:15 Presidential Address
Peter McGuffin (Cardiff, UK)

09:30-11:30
Plenary Session 1 - Hall 3:
Perspectives from Neurobiology
Chair: Peter Propping, Bonn

09:30 The Genetics of Pre synaptic Functions
Thomas C. Südhof (Dallas, TX, USA)

10:10 Variation in Key Human Cholinergic Genes-Relationship to CNS Disorders
Herrnona Soreq (Jerusalem, Israel)

10:50 Fragile X Syndrome is Caused by a Fragile Gene
Ben A. Oostra (Rotterdam, The Netherlands)

12:00-14:00
Poster Session - Castle
Authors of posters no. 1-85 should be at their posters

14:00-15:45
Concurrent Session 1 - Hall 1:
Genome-Wide Screens in Schizophrenia
Chair: John 1. Nuremberger, Indianapolis
Michael Owen, Cardiff

14:00 Progress of Genome Scan of the NIMH Intramural Schizophrenia Collection
Pablo V. Gejman (Chicago, IL, USA) et al.

14:15 A Two-Stage Sib-Pair Genome Scan for Schizophrenia Susceptibility Genes
Nigel M. Williams (Cardiff, UK) et al.

14:30 A Search for Schizophrenia Loci in Multiple Study Samples in Finland
Jesper Ekelund (Helsinki, Finland) et al.

14:45 A Genome-Wide Search for Schizophrenia Genes in an Internal Isolate of Finland Suggesting Multiple Susceptibility Loci
Iids Hovafta (Helsinki, Finland)
et al.

15:00 Genome Scan for Autosomal Genes Conferring Risk to Schizophrenia in a Germanilsraeli Sample
Dieter B. Wildenauer (Bonn, Germany) et al.

15:15 Multigenic Inheritance of Schizophrenia: A Genome Scan Identifies Susceptibility Loci on Chromosomes 13q32 and 8p21
Ann E. Pulver (Baltimore, MD, USA)

15:30 Genome-Wide Scan and Schizophrenia in African Americans
David L. Garver (Dallas, TX, USA) et al.

14:00-16:00
Concurrent Session 1 - Hall 2:
Genetic Epidemiology
Chair: Stephen V. Faraone, Boston
Wolfgang Maier, Bonn


14:00 Life Events, Cognitions, Attributions, and Personality are Familial in Major Depression
Anne E. Farmer (Cardiff, UK) et al.

14:15 The Genetic Epidemiology of Major Depression
Kenneth S. Kendler (Richmond, VA, USA) et al.

14:30 A Controlled Community-Based Family Study of Major Depression with Postpartum Onset
L. Abramov and Ada H. Zohar (Jerusalem, Israel)

14:45 The Overlap of Depression and Generalized Anxiety Disorder: A Study of Male Twins
Michael J. Lyons (Boston, MA, USA) et al.

15:00 Reproductive Pathology and Offspring Outcomes in Women with Schizophrenia and Affective Psychoses: Genetic Vulnerability or Environmental
Risk?
Assen Jablensky (Perth, Australia) et al.

15:15 Concordance Rates and Biometrical Model Fitting for Operational Diagnoses in the Maudsley Twin Psychosis Series
Alastair G. Cardno (Cardiff, UK) et al.

15:30 Schizophrenics and their Adopted-Away Offspring. The Finnish Adoptive Family Study of Schizophrenia
Pekka Tienah (Ouiu, Finland) et al.

15:45 Risks for Primary Progressive Dementia and for Depression in First-Degree Relatives of Patients with Alzheimers Disease and Geriatric Depression
Reinhard Heun (Bonn, Germany) et al.

14:00-16:00
Concurrent Session 1 - Hall 4:
Genetics of Childhood Onset Disorders
Chair: Raymond R. Crowe, lowa City
Susan Folstein, Boston


14:00 The Dopamine D4 Gene 7-Repeat Allele is Associated with ADHD in Families Ascertained through ADHD Adults
Stephen V. Faraone (Boston, MA, USA) et al.

14:15 Molecular Genetics of Nocturnal Enuresis
Alexander von Gontard (Cologne, Germany) et al.

14:30 Genetic and Environmental Influences in the Development of Attention Deficit Hyperactivity Disorder
Susan L. Smalley (Los Angeles, CA, USA) et al.

14:45 A Molecular Genetic Study of Hyperkinetic Disorder/Attention Deficit Hyperactivity Disorder
K. Poulton (Manchester, UK) et al.

15:00 The Nature of Genetic lnfluences in Predicting Persistent Antisocial Behavior
Emily Simonoff (London, UK) et al.

15:15 The Relation between Childhood Antisocial Behavior and the Dopamine Transporter Gene (DAT1): Mediatiori via Hyperactivity-Impulsivity
lrwin D. Waldman (Atlanta, GA, USA) et al.

15:30 A Linkage Study of Spelling Disorder on Chromosomes 1, 6 and 15
Gerd Schulte-Köme (Marburg, Germany) et al.

15:45 Screening of Candidate Genes in Patients with Anorexia Nervosa
Anke Hinney (Marburg, Germany) et al.

16:30-
Chromosome Workshops:
Chromosome 4 - Hall 1
Chair: James Kennedy, Toronto
Chromosome 8 and 10 - Hall 2
Chair: Dieter B. Wildenauer, Bonn
Chromosome 6 - Hall 4
Chair: John 1. Nurnberger Jr, Indianapolis
Chromosome 5 - Hall 5
Chair: Raymond R. Crowe, lowa City

Thursday, October 8, 1998

08:30-10:30
Plenary Session 11 - Hall 3:
Biometric Methods
Chair: Theodore Reich, St. Louis

08:30 Family-Based Association Tests
Max P. Baur (Bonn, Germany)

09:1 0 The Use of Covariates in Affected Sib-Pair Analyses
John P. Rice (St. Louis, MO, USA)

09:50 Quantitative Trait Locus Mapping Methods for Complex Phenotypes: The State-of-the-Science
John Blangero (San Antonio, TX, USA)

11:00-13:00
Concurrent Session 11 - Hall 1:
Genome-Wide Screens in Affective Disorder
Chair: Miron Baron, New York
Markus M. Nöthen, Bonn


11:00 Overview of Genome Scans on Schizophrenia and Bipolar Disorder
Timothy J. Crow (Oxford, UK) and
Lynn E. DeLisi (Stony Brook, NY, USA)

11: 15 The Welcome Trust UK-Irish Bipolar Sib-Pair Study:
Sample and Study Design
Michael Gill (Dublin, Ireland) and
Nick Craddock (Birmingham, UK) for the Welcome
Trust Bipolar Group


11:30 A Genome Survey of Bipolar Disorder Indicates a Susceptibility Locus on Chromosome 22
John R. Kelsoe (La Jolla, CA, USA) et al.

1 1:45 A Genome-Wide Scarl for Bipolar Affective Disorder
Jianjun Liu (New York, NY, USA) et al.

12:00 Genome-Wide Scan of Affected Relative Pairs Using the NIMH Genetics Initiative Bipolar Affective Disorder Pedigrees
Tatjana Foroud (Indianapolis, IN, USA) et al.

12:15 Results of a Genome Screen for Genes Predisposing for Major Affective Disorder in Two Large Kindreds
Daniela S. Gerhard (St. Louis, MO, USA) et al.

12:30 Evidence for a Susceptibility Locus for Bipolar Disorder on Chromosome 1 1 pl 1.5
Melvin G. Mclnnis (Baltimore, MD, USA) et al.

12:45 Genome Screen and Candidate Gene Analysis in Bipolar Disorder
Sevilla D. Detera-Wadleigh (Bethesda, MD, USA) et al.

11:00-13:00
Concurrent Session 11 - Hall 2:
Analysis of Complex Genetic Traits
Chair: Peter McGuffin, Cardiff
Fabio Macciardi, Milano

1 1:00 PsycheMap - An Interactive Internet-Based Database of Psychiatric Genetics Linkage, Association and Genome Mapping Projects
Nigel M. Wiiliams (Cardiff, UK) et al.

1 1: 1 5 Non-Paramedic Methods for Localization of Genes for Complex Traits Using Ancestral Haplotypes
Rory B. Martin and
C.J. MacLean (Richmond, VA, USA)


11:30 Bernstein, Hogben, and Penrose. Sib-Pairs and Other Subsets
John H. Edwards (Oxford, UK)

11:45 A Structural Equation Modeling Approach to the Analysis of Allelic Associations between Markers and Quantitative Trait Loci
Edwin J.C.G. Van den Oord (London, UK)


12:00 Structural Decomposition of Genetic Diversity in Schizophrenic, Schizoaffective and Bipolar Patents
Hans H. Stassen (Zurich, Switzerland) et al.

12:15 Detecting QTLs for Uni- and Bipolar Disorder Using a Vadance Component Method
Peter M. Visscher (Edinburgh, UK) et al.

12:30 Segregation Models and Parental Transmission in Bipolar 1 Disorder:
Maria Serbanescu-Grigoroiu (Bucharest, Romania) et al.

12:45 The Fronto-Temporal Dementia Locus on Chromosome 17
Cohnne L. Lendon (Birmingham, UK) for the FTDP-17 Consortium

11:00-13:00
Concurrent Session 11 - Hall 4:
Candidate Genes
Chair: David A. Collier, London
David Goldman, Rockville

1 1:00 Association between Alzheimers Disease and NOS3 Gene
Mohammed Dahiyat (Aberdeen, UK) et al.

11:15 Serotonin Transporter Gene Polymorphisms in Unipolar and Bipolar Depression
Frank Beilivier (Paris, France) et al.

11:30 No Association between Serotonin Transporter or Tryptophan Hydroxylase Promoters and Bipolar Disorder with or without Suicidal Behavior
Alessandro Rotondo (Pisa, Italy) et al.

11:45 Further Support for an Association between a Polymorphic Repeat in the hKCa3 Gene and Schizophrenia but no Evidence for
Association with Bipolar Disorder
Timothy Bowen (Cardiff, UK) et al.

12:00 Identification of a British Cohort of Patients with a Phenotype Similar to that Found to be Associated with a Premature Stop
Codon in the Monoamine Oxidase A (MAOA) Gene
Rebekah Stamps (London, UK) et al.

12:15 Genetic Variants of Dopamine Receptor D, and Psychopathology
Alessandro Serretti (Milano, Italy) et al.

2:30 Dopamine D, Receptor (D4DR) and Serotonin Transporter Promoter (5-HTTLPR) Polymorphisms in the Determination of perament in Two-Month Old Infants
Richard P. Ebstein (Jerusalem, Israel ) et al.

12:45 Reflections on the Nature of the X-Y Homologous Gene that Determines Cerebral Asymmetry
Timothy J. Crow (Oxford, UK)

13:30-15:30
Poster Session - CasUe
Authors of posters no. 86-191 should be at their posters

15:30-16:45
Concurrent Session 111 - Hall 1:
New Genetic Technologies
Chair: Leena Peltonen, Helsinki
Sven Cichon, Bonn

15:30 Region Specific Isolation and Characterization of Triplet Repeats
Dirk Goossens (Antwerp, Belgium) et al.

15:45 DNA Pooling for Genomic Scanning - Application to an Association Study
Paul J. Fisher (Cardiff, UK) et al.

16:00 The Development of a DNA Pooling Methodology, its Application to Both Simple Sequence Repeats and Single Base Pair Substitutions and the
Determination of its Sensitivity via a Spiking Methodology
Gerome Breen (Aberdeen, UK) et al.

16:15 Genotyping Single Nucleotide Polymorphisms by Primer Extension and High Performance Liquid Chromatography
Bastiaan Hoogendoorn (Cardiff, UK) et al.

16:30 Multiconditional SSCP (M-SSCP) for VAPSE-Based Analysis of Complex Disorders: A Type of Candidate Gene Approach
Applied to Schizophrenia and Other Psychiatric Diseases
Steve Sommer (Duarte, CA, USA) et al.

15:30-16:45
Concurrent Session 111 - Hall 2:
Genetic Findings in Schizophrenia
Chair: Douglas Blackwood, Edinburgh
Kenneth S. Kendler, Richmond


15:30 Search for Schizophrenia Loci in a Swedish Geographic Isolate
Lennart Wetterberg
(Stockholm, Sweden/Tromso, Norway) et al.


15:45 Progress in Locating a Gene for Schizophrenia on the Sex Chromosomes
Lynn E. DeLisi (Stony Brook, NY, USA) et al.

16:00 Haplotype Analysis of Chromosome 8p and 15q in Icelandic Schizophrenic Patients
Hans W. Moises (Kiel, Germany) et al.

16:15 Linkage Disequilibrium Mapping of Chromosome 22 in Schizophrenia Using DNA Pooling on Chinese and Scottish Populations
David A. Collier (London, UK) et al.

16:30 Analysis of Genes Neighboring a Balanced Translocation Associated with Schizophrenia
Rebecca S. Devon (Edinburgh, UK) et al.

15:30-16:45
Concurrent Session 111 - Hall 4:
Animal Models
Chair: Wim E. Crusio, Orläans
James Kennedy, Toronto

15:30 Apomorphine-Susceptible Rats: A New Tool in the Search after Schizophrenia
Alexander R. Cools and B.A. Ellenbroek (Nijmegen, The Netherlands)

15:45 Quantitative Trait Loci for Traits Related to Affective Disorder in Inbred Strains of Mice
John 1. Nurnberger, Jr. (Indianapolis, IN, USA)

16:00 QTL Analysis Reveals a Complex Genetic Basis for Emotionality Traits in Rats
Pierre Mormäde (Bordeaux, France) et al.

16:15 A Major Chromosomal Locus Influences Behavioral Hyperactivity in Rat Made-Pierre Moisan (Bordeaux, France) et al.

16:30 The Effects of Prenatal Exposure to Ethanol on Hippocampal Neuroanatomy and Spatial Learning in a Radial Maze in Three Inbred Mouse Strains
Wim E. Crusio (Orleans, France) et al.

17:00-19:00
Chromosome Workshops:
Chromosome 18 - Hall 1
Chair: Christine Van Broeckhoven, Antwerp
Chromosome 11, 14, and 15 - Hall 2
Chair: Nick Craddock, Birmingham
Chromosome 22 - Hall 4
Chair: Sibylle Schwab, Bonn
Chromosome 1, 2, and 7 - Hall 5
Chair: Joachim Hallmayer, Mt. Claremont

Friday, October 9, 1998

8:30-11:00
Plenary Session 111 - Hall 3:
Past and Future of Psychiatric Genetics
Chair: Irving 1. Gottesman, Charlottesville

08:30 Psychiatric Genetics in Germany 1939-1945: Can Anything be Learned from History?
Benno Müller-Hill (Cologne, Germany)

09:1 0 Through the Lens of Justice: The Origins and Significance of Nazi Euthanasia from the Perspective of the Nuremberg Medical Trial
Paul Weindling (Oxford, UK)

09:50 Genetic Research in the Context of Nazi Euthanasia: New Documents and Aspects on Ernst Rüdin and the Deutsche Forschungsanstalt für Psychiatrie
Volker Roelcke (Bonn, Germany) et al.

10:20 Genetic Discoveries in Psychiatry and their Impact on the 21 st Century
Elliot S. Gershon (Chicago, IL, USA)

11:30-13:30
Concurrent Session IV - Hall 1:
Genetic Findings in Affective Disorder
Chair: Michael Gill, Dublin
Hiroshi Yoneda, Osaka


11:30 Genetic Linkage to Chromosome 4q35 in Bipolar Affective Disorder
Peter R. Schofield (Sydney, Australia) et al.

1 1:45 Confirmation of Bipolar Affective Disorder Susceptibility Locus on Chromosome 12 in the Region of the Darier Disease Gene
Nicholas Barden (Ste-Fay, Canada) et al.

12:00 Studies of Bipolar Disorder on Chromosome 12q23-q24.1 in the Region of the Daders Disease Gene
Nick Craddock (Birmingham, UK) et al.

12:15 Identification of a Gene for Susceptibility to Bipolar Affective Disorder
Kathryn L. Evans (Edinburgh, UK) et al.

12:30 Manic Depressive Disorder and Chromosome 18
Sandra M. Villafuerte (Antwerp, Belgium)

12:45 Sibs Affected with BP 11 are More Likely than Sibs with BP 1 to Share the Linked Region on Chromosome 18q21
Francis J. McMahon (Baltimore, MD, USA) et ai.

13:00 A Follow-Up Linkage Analysis of Chromosome 21 Continues to Provide Evidence for a Putative Bipolar Affective Disorder Locu
Vincent M. Aita (New York, NY, USA) et al.

13:15 Family-Based Association Studies of Candidate Genes in Bipolar Disorder
George Kirov (Cardiff, UK) et al.

11:30-13:30
Concurrent Session IV - Hall 2:
Pharmacogenetics/Alcoholism
Chair: Pablo Gejman, Chicago
Marcella Rietschel, Bonn


Pharmacogenetics:

11:30 Genetic Factors in Tardive Dyskinesia: Possible Role of the Dopamine Transporter
Ronnen H. Segman (Jerusalem, Israel)

11:45 Allelic Vadabon in the Promoter Region of the Dopamine D 2 Receptor Gene Influences the Antipsychotic Response to Clozapin
Anil Malhotra (Glen Oaks, NY, USA) et al.

12:00 Association Studies and Clinical Response: Analysis of Extreme Responders
Maria J. Arranz (London, UK) et al.

12:15 Effect of Lithium Treatment on the Ga-olf Protein in Transformed Lymphoblastoid Cell Lines Derived from Unaffected and Bipolar Affective Disorder Subjects
Debomoy K. Lahid (Indianapolis, IN, USA) et al.

Alcoholism:

12:30 Replicating Genetic Linkage in the Collaborative Study on the Genetics of Alcoholism (COGA)
Theodore Reich (St. Louis, MO, USA) et al.

12:45 Linkage of an Alcoholism-Related Severity Phenotype to Chromosome 16
Tatjana Foroud (Indianapolis, IN, USA) et al.

13:00 Linkage of the 5-HT1, Serotonin Receptor to Antisocial Alcoholism in Finns and Southwestern Indians
David Goldman (Rockville, MD, USA) et al.

13:15 Possible Association of the Serotonin Transporter Gene väth Alcoholism/Antisocial Personality
Abbas Parsian (St. Louis, MO, USA) et al.

11:30-13:30
Concurrent Session IV - Hall 4:
Neurobiology of Mental Disease/Genes for Autism
Chair: Elliot S. Gershon, Chicago
Peter Falkai, Bonn

Neurobiology of Mental Disease:

1 1:30 Abnormal Expression of Neuronal Nicofinic Acetylcholine Receptors in Schizophrenia
Sherry Leonard (Denver, CO, USA) et al.

11:45 Polymorphic Imprinting of the Serotonin-2A (5-HT2A) Receptor Gene in Human Adult Brain
Roland Bunzei (Bonn, Germany) et al.

12:00 The Munich Vulnerability Study on Affective Disorders: The Current State-of-the-Art
Sieglinde Modell (Munich, Germany) et al.

12:15 Repeat Expansions in Neuropsychiatric Disorders
Kerstin Lindblad (Stockholm, Sweden) et al.

Genes for Autism:

12:30 A Genome-Wide Search for Autism Susceptibility Genes
Anne Philippe (Paris, France) et al.

12:45 Searching for Susceptibility Genes for Infantile Autism
Sabine M. Klauck (Heidelberg, Germany) et al.

13:00 A Genome Screen of 76 Families Ascertained through Two Autism Probands
Susan Folstein (Boston, MA, USA) for the Collaborative Linkage Study of Autism (CLSA)

13:15 Autism Associated with Chromosome 22
James Wilcox (EI Paso, TX, USA)

14:00-15:30
Poster Session - Castle
Authors of posters no. 192-250 should be at their posters

15:30-17:30
Chromosome Workshops:
Chromosome 3 and 9 - Hall 1 (15:30-16:30)
Chair: Vishwajit L. Nimgaonkar, Pittsburgh
Chromosome 13 and 17 - Hall 1 (1 6:30-17:30)
Chair: Nicholas Barden, Ste-Foy
Chromosome 19 and 20 - Hall 2 (15:30-16:30)
Chair: Pablo V. Gejman, Chicago
Chromosome X - Hall 2 (16:30-17:30)
Chair: Andrew Paterson, Toronto
Chromosome 12 and 16 - Hall 4
Chair: Sevilla D. Detera-Wadleigh, Bethesda
Chromosome 21 - Hall 5
Chair: David Curtis, London

Saturday, October 10, 1998

09:00-11:00
Plenary Session IV - Hall 3:
New Genetic Technologies
Chair: Christine Van Broeckhoven, Antwerp

09:00 Analysis of Gene Function in Vivo by Conditional Targeted Mutagenesis
Klaus Rajewsky (Cologne, Germany)

09:40 New Genetic and Genomic Technologies for Dissecting Complex Diseases Aravinda Chakravarti (Cleveland, OH, USA)

10:20 Legal and Ethical Problems of Patenting Human Genes
Joseph Straus (Munich, Germany)

12:00-15:00
Plenary Session V - Hall 3:
Chromosome Workshop Reports
Chair: Timothy J. Crow, Oxford
Lynn DeLisi, Stony Brook


15:00-15:30
Poster Breakdown - Castle


Poster Presentations


I. Animal Models

1. Stereological Estimation of the Total Number of Neurons in the Murine Hippocampus Using the Optical Disector
I. Abusaad (London, UK) et al.

2. Arachidonic Acid and its Metabolites are Involved in the Expression of Neocortical Spike-and-Wave Spindling Episodes in DBA/2J Mice
A. Capasso (Penta di Fisciano, Italy) and A. Loizzo (Roma, Italy)

3. Increased Defensive-Aggressive Behavior in Adult Mice Produced by Monoamine Oxidase Inhibition During Neurodevelopment
J.M. Mejia (Montreal, Canada) et al.

4. Involvement of the Dopamine Receptor Genes in Individually Different Apomorphine-Induced Motility
S. Germeyer (Mainz, Germany) et al.

5. Antidepressant-Induced Changes of Gene Expression in the Rat Brain Detected by Differential Display PCR
D. Hranilovic (Zagreb, Croatia) et al.

6. Suggestive Evidence for a Quantitative Trait Locus on Chromosome 3 for Prepulse Inhibiton in the Mouse
A.R. Sanders (Bethesda, MD, USA) et al.

7. Amphetamines Induce Apoptosis in Rat Cortical Neurons
J. Schlegel (Marburg, Germany) et al.

II. New Genetic Technologies

8. Advances in Gene Mapping Technology: SNPS, Chips, and Rolling Circles
R. Lasken (New Haven, CT, USA) et al.

9. Screening the Critical Region on Chromosome 4p with DNA Pooling for Association with Bipolar Disorder
N. Williams (Cardiff, UK) et al.

1 0. QTLs for General Cognitive Ability in Children: DNA Pooling for
Chromosome 22
L. Hill (London, UK) et al.

1 1. Analysis of Individual Chromosomes in Brain Tissue Sections by Multicolor FISH
Y.B. Yurov (Moscow, Russia) et al.

III. Analysis of Complex Genetic Traits

12. Search for Susceptibility Loci on Selected Chromosomes Including a Dinucleofide Repeat Polymorphism at the CCKBR Locus in
Patients with Panic Disorder from the Faroe Islands
B. Degn (Aarhus, Denmark) et al.

13. The Use of Extremely High and Low Scoring Individuals on Temperament Scales in Genetic Analyses: A Power Calculation
S. Van Gestel (Antwerp, Belgium) et al.

14. Association Study of Extreme High and Low Neuroticism with Genetic Markers for the Dopaminergic System
T.C. Eley (London, UK) et al.

15. Sib-Pair Linkage and Association Analysis of the Serotonin Transporter Promoter Polymorphism and TPQ Personality Traits
C. Mazzanti (Rockville, MD, USA) et al.

16. A New Strategy for the Genetic Analysis of Anxious Temperament
J.W. Smoller (Boston, MA, USA) et al.

17. Integration of Genetic Maps by Polynomial Transformations
H.H. Stassen and C. Scharfetter (Zurich, Switzerland)

18. Genetic Linkage Analysis with Monte Cado Markov Chain (MCMC) Techniques for Multipoint Analyses in Complex Pedigrees
F. Macciardi and A. Morabito (Milano, Italy)

19. Multiple Additive Associations: A Technique for the ldentification of Genes in Polygenic Disorders
D. Comings (Duarte, CA, USA) et al.

20. What Does Discordance Mean in Monozygotic Twins?
C.L. Smith (Boston, MA, USA) et al.

21. Using Consensus OPCRIT Diagnoses: An Efficient Procedure for Best Estimate Lifetime Diagnoses
M.H. Azevedo (Coimbra, Portugal) et al.

22. Genetic Analysis of Bipolar Disorders: Epistatic Effects between Candidate Genes
M. Corbex (Paris, France) et al.

23. Differences in Recurrence Risk by Birth Order of the First Affected Child Provide Evidence of Genetic Heterogeneity
L. Zwaigenbaum (Hamilton, Canada) et al.

24. A Twin Study of Gene-Environment Interaction in Generalized Anxiety Disorder
F.A. O'Neill (Belfast, UK) and K.S. Kendler (Richmond, VA, USA)

IV. Genetic Epidemiology

25. Reduced Prevalence of Psychoses in a Genetic Isolate?
V.L. Nimgaonkar (Pittsburgh, PA, USA) et al.

26. A Genetic Founder Effect in Mental Disorders
J.E. Andersen and T. Hynnekleiv (Oslo, Norway)

27. Early and Late Onset Bipolar Disorders: A Clinical and Family Study
F. Schürhoff (Paris, France) et al.

28. The Relationship between Alcoholism and Bipolar Affective Disorder: Association in Families of Comorbid Probands
J.B. Potash (Baltimore, MD, USA) et al.

29. From Pedigree to Population Studies in Bipolar Disorders
C. Peffi (Lamezia Terme, ltaly) et al.

30. Admixture Analysis among African-Americans wb Schizophrenia and Controls
F. Zhang (Pittsburgh, PA, USA) et al.

31. Family Differences in Personality: A Multigenerational Study of 67 Families
M. Lundberg (Umeä, Sweden) et al.

32. Increased Suicide Rates in Relatives of Psychiatric OutPatients with Low Cholesterol Concentration
A. Bocchefta (Cagliah, Italy) et al.

33. Heritability of Binge-Eating and Bulimia Nervosa
C.M. Bulik (Richmond, VA, USA) et al.

34. Diagnostic Boundaries in Psychiatric Genetics
M. Ast (Glen Oaks, NY, USA) and S.L. Wieder (Rock Hill, NY, USA)

V. Ethical Issues

35. Philosophy of Psychiatric Genetics
S.L. Wieder (Rock Hill, NY, USA) and M. Ast (Glen Oaks, NY, USA)

36. Psychiatric Genetics: Freedom vs. Causality
S.L. Wieder (Rock Hill, NY, USA) and M. Ast (Glen Oaks, NY, USA)

37. Genetics and Mental Disorders: The Ethical Context
F. Caldecoft (Oxford, UK) for Working Party on Genetics and Mental Disorder

Vl. Neurophysiological Markers

38. Childhood Neurobehavioral Deficits in Offspr(ing at Risk for Schizophrenia in the New York High-Risk Project: Sibling Correlations
and Relationship to Future Schizophrenia
L. Edenmeyer-Kimling (New York, NY, USA) et al.

39. Measures of Predictive Smooth Pursuit in Relatives of Patients with Schizophrenia
G.K. Thaker (Baltimore, MD, USA) et al.

40. Topographical EEG Changes during Mental Tasks Associated with Genetic Predisposition to Schizophrenia
L.G. Uvarova (Moscow, Russia) et al.

41. The Neurophysiological Markers of Cognitive Dysfunction in Adolescent Depression
E.S. Mikhailova and 1.V. Oleichik (Moscow, Russia)

42. Pleiotropic Genetic Influences on Event-Related Brain Potenbals and Alcoholism
L. Almasy (San Antonio, TX, USA) et al.

43. P300 in Monozygotic Schizophrenic Twins
M. Weisbrod (Heidelberg, Germany) et al.

44. P300 in the Families of Schizophrenics
1.S. Lebedeva (Moscow, Russia) et al.

VII. Candidate Genes

Dopamine Receptors

45. A Genetic PET Scan Study: Di Alieles Predict Clinical Response to Clozapine and Corresponding Brain Metabolism
S.G. Potkin (Irvine, CA, USA) et al.

46. Comparative Measurement of Allelic Dopamine D2 Receptor Gene (DRD2) Expression in Cultured Lymphocytes from Blood
Samples
M. Kabc (Hamburg, Germany/Zagreb, Croaba) et al.

47. Association between a Promoter Polymorphism in the Dopamine D2 Receptor Gene and Schizophrenia
E.G. Jönsson (Stockholm, Sweden) et al.

48. Polymorphisms in the Dopamine D2 Receptor Gene and their Reiatonships to Striatal Dopamine Receptor Density in Vivo of Healthy Volunteers
E.G. Jönsson (Stockholm, Sweden) et al.

49. An Association Study between Atypical Psychoses and Dopamine D2 Receptor Gene
J. Koh (Osaka, Japan) et al.

50. No Association of Novelty Seeking with DRD3 and DRD2 Receptor Gene Polymorphisms
C. Gebhardt (Vienna, Austria) et al.

51· Schizophrenia and DRD3 among Indian Families
S. Prasad (Pittsburgh, PA, USA) et al.

52. Dopamine D, Receptor Gene Variants and Susceptibility to Early Dyskinesia
T. Rohrmeier (Regensburg, Germany) et al.

53. Dopamine D,-Receptor Polymorphism in Affective and Schizophrenic Disorders
A. Putzhammer (Regensburg, Gerrnany) et al.

54. Homozygosity for the Ser9Gly Variant of the Dopamine D, Receptor and Risk for Tardive Dyskinesia in Schizophrenic Patients: A Follow-Up Study
V.M. Steen (Bergen, Norway) et al.

55. Association of Dopamine D, Receptor Gene Polymorphism and Response to Clozapine
J. Scharfetter (Vienna, Austria) et al.

56. Tardive-Dyskinesia is not Associated to Dopamine D3- and Dopamine-ß-Hydroxylase-Genes in Austrian Schizophrenics
H.N. Aschauer (Vienna, Austria) et al.

57. The Dopamine Hypothesis in Schizophrenia Tested with the Haplotype Relative Risk Method
C. Dubertret (Colombes, France) et al.

Dopamine Transporter

58. Systematic Search for Variation in the Human Dopamine Transporter Gene
F. Grünhage (Bonn, Germany) et al.

59. Mutation Screening of the Dopamine Transporter Gene in Bipolar Disorder
T.A. Greenwood (San Diego, CA, USA) et al.

60. No Association between a Variable Number of Tandem Repeat (VNTR) in the 3' Untranslated Region of the Dopamine Transpo
Gene (DAT1) and Bipolar Affective Disorder
J.T.P. Birkett (London, UK) et al.

61. Attention Deficit Hyperactivity Disorder: Association with the Dopamine Transporter (DAT1) but not with the Dopamine D4 Receptor (DRD4)
G. Daly (Dublin, Ireland) et al.

Serotonin Receptors

62. Implication of 5-HT2A Gene Promoter Polymorphism in Anorexia Nervosa
B. Nacmias (Florence, Italy) et al.

63. 5-HT2A Mspi Polymorphisms are not Associated with Anorexia Nervosa in a Population of French Female Patients
P. Gorwood (Colombes, France) et al.

64. The 5-HT2A -1 348G/A Polymorphism as a Susceptibility Factor for Anorexia Nervosa
D.A. Collier (London, UK) et al.

65. Association between 5-HT2A Promoter Polymorphism -1438G/A and Obsessive-Compulsive Disorder
M.-A. Enoch (Rockville, MD, USA) et al.

66. A European Multicenter Association Study with 5-HT2, Receptor Polymorphism in Unipolar and Bipolar Affective Disorders
I. Massat (Brussels, Belgium) et al.

67. Association Study of the Serotonin 2A Receptor Gene Polymorphism wb Personality Traits in Patients with Schizophrenia and Healthy Controls
V.E. Golimbet (Moscow, Russia) et al.

68. Alielic Association Analysis of 5-HT2A Receptor Polymorphisms and Response to Clozapine
S. Pedhni (Milano, Italy) et al.

69. Assignment of the Human Serotonin 4 Receptor Gene (HTR4) to the Long Arm of Chromosome 5 (5q31-q33)
K. Kesper (Bonn, Germany) et al.

70. Association Study of the 5-HT6 Receptor Gene in Schizophrenia
T. Shinkai (Kitakyushu, Japan) et al.

71. An Association Study between Alcoholism and Serotonergic Receptor Genes
A. Himei (Osaka, Japan) et al.

72. Mutational Analysis of the 5-HT1, and 5-HT1E Serotonin Receptor Genes in three Datasets wb Schizophrenia
J. Taylor (Bethesda, MD, USA) et al.

Serotonin Transporter

73. What does the Serotonin Transporter Promoter Polymorphism Stand for in Major Depression?
A. Putzhammer (Regensburg, Germany) et al.

74. No Evidence of an Association between Bipolar Disorder and the Serotonin Transporter in the Irish Population
L. Myneft-Johnson (Dublin, Ireland) et al.

75. Evidence of Association between the Long Allele in Serotonin Transporter Gene and Depressed Suicide
L. Du (Ottawa, Canada) et al.

76. Serotonin Transporter Gene Variants in Affective and Schizophrenic Disorders
A. Schoeler (Regensburg, Germany) et al.

77. Tourefte's Syndrome and 5-HTT: An Association Study Using The HRR Strategy
M.C. Cavallini (Milano, Italy) et al.

78. No Association between Obsessive-Compulsive Disorder and 5-HTT Gene
M.C. Cavallini (Milano, Italy) et al.

79. Serotonin Transporter Gene Variants and Severity of Alcohol Dependence
P. Eichhammer (Regensburg, Germany) et al.

80. No Association between Childhood Onset Disorder and Serotonin Transporter Using a Haplotype Relative Risk Approach
M. Nobile (Bosiso Padni, Italy) et al.

81. Familial Morbid Risk for Severe Psychiatric Disorders Increases in Bipolar Patients with Dosage of SERT Alleles 484 and SUn2.1
B. Gutiérrez (Barcelona, Spain) et al.

82. 5-HTT Genetic Polymorphisms, Alcoholism and Suicidal Behavior
P. Gorwood (Colombes, France) et al.

Opioid Receptors

83. Genetic Variability of the Human Mu Opioid Receptor Gene and its Implication for Substance Abuse
M.R. Hoehe (Berlin, Germany) et al.

84. Possible Association of the Common Asn40Asp Substitution Polymorphism of the Human poploid Receptor Gene with Novelty
Seeking in Alcohol Dependent Subjects
L.G. Schmidt (Berlin, Germany) et al.

85. uOpioid Receptor Variation and Dopaminergic Sensitivity in Alcoholics
M. Smolka (Berlin, Germany) et al.

86. Lack of Association between the hSKCa3 Channel Gene CAG Polymorphism and Schizophrenia
R. Joober (Verdun, Canada) et al.

87. No Evidence to Support the Association of the Potassium Channel Gene hSKCa3 CAG Repeat with Schizophrenia or Bipolar Affective Disorder in Irish Population
Z. Hawi (Dublin, Ireland) et al.

88. Inheritance of a CAGICTG Repeat in the hKCa3 Gene in Families with Bipolar Affective Disorder
I.V. Meira-Lima (Sao Paulo, Brazil) et al.

89. hKCa, a Candidate for Bipolar Affective Disorder?
P. Eichhammer (Regensburg, Germany) et al.

Cholinergic Receptors

90. Schizophrenia, Smoking and the a7 Nicofinic Receptor Gene
G. McCarthy (Cardiff, UK) et al.

91. Phenotypic Expression of Neuronal Nicotinic Aoetylcholine Receptor Gene (CHRNA4) in Stressed and Unstressed Subjects
D.E. Comings (Duarte, CA, USA) et al.

Adrenergic Receptors

92. Genetic Variation in (x2A Adrenergic Receptors and Schizophrenia
M.J. Arranz (London, UK) et al.

93. Structural Polymorphism in the a2B Adrenoreceptor: No Association with Schizophrenia or Clozapine Responsiveness
H.0. Kalkman (Basel, Switzerland) et al.

Tyrosine Hydroxylase

94. Evidence for a Functional Role on Gene Transcription of a Polymorphic Tetrarepeat Sequence in the Tyrosine Hydroxylase Gene that is Associated with Psychiatric Diseases
V. Albanèse (Paris, France) et al.

95. Search of Polymorphisms in the 3'UTR of the Tyrosine Hydroxylase Gene
R. Meloni (Paris, France) et al.

96. Family-Based Association Study between the Tyrosine Hydroxylase Locus and Bipolar Affective Disorders
M. Nosten-Bertrand (Paris, France) et al.

97. Tyrosine Hydroxylase Polymorphism and Phenotypic Heterogeneity in Unipolar Affective Disorder: A European Multicenter Association Study
D. Souery (Brussels, Belgium) et al.

98. Manic Depression and Tyrosine Hydroxylase: A Linkage and Association Study
R. Segurado (Dublin, Ireland) for the Wellcome Trust UK/Irish Study of Bipolar Sib Pairs


Tryptophan Hydroxylase


99. Study of Tryptophan Hydroxylase Gene (TPH) Polymorphisms in Bipolar Patients and Suicide Attempters
A. Paoloni-Giacobino (Genova, Switzerland) et al.

100. Association between the Tryptophan Hydroxylase Gene and Suicidal Behavior in Bipolar Patients
F. Bellivier (Paris, France) et al.


101. No Allelic Association between Bipolar Affective Disorder and the Tryptophan Hydroxylase Gene (TPH)
A. McQuillin (London, UK) et al.

102. Association Study of the Tryptophan Hydroxylase Gene and Bipolar Affective Disorder Using Family-Based Internal Controls
M. Rietschel (Bonn, Germany) et al.

103. Allelic Association Analysis of the Tryptophan Hydroxylase Gene and Criminal Behavior in a Population of Male Schizophrenia Patients
M. Verga (Milano, Italy) et al.

Monoamine Oxidase

104. Detailed Analysis and Classification of a Complex VNTR in the First Intron of the Monoamine Oxidase A Gene and New SSR
Variants in and Flanking the MAOB Gene
H.G. Koch (London, UK) et al.

105. Analysis of the Monoamine Oxidase Genes and the Norrie Disease Gene Locus in Narcolepsy
H. Koch (London, UK) et al.

106. Evidence for Association of a MAO-A Promoter Polymorphism with Panic Disorder in Female Patients
J. Deckert (Würzburg, Germany) et al.

107. Relationship between Polymorphic Markers at the Human Monoamine Oxidase Locus and Platelet Enzymatic Activity
J.M. Mejia (Montreal, Canada) et al.

108. Antisocial Personality Tendencies in Male Alcoholics Associated with a Polymorphism in the Promoter Region of the X-Linked MAOA Gene
J. Samochowiec (Szczecin, Poland/Bedin, Germany) et al.

COMT

109. Further Evidence of Transmission Disequilibrium of the Catechol-O-Methyltransferase (COMT) Gene in Schizophrenia in a
Chinese Population
T. Li (London, UK/Sichuan, China) et al.

1 1 0. Association between the Genetic Polymorphism of the Catechol-O-Methyltransferase (COMT) and Type 1 Alcoholism
J. Tiihonen (Kuopio, Finland) et al.

1 1 1. No Association between Obsessive Compulsive Disorder and the COMT Gene
D. Di Bella (Milano, Italy) et al.

Aggressive, Violent and Dangerous Behavior Associated with a Polymorphism Determining High and Low ol-O-Methyltransferase (COMT) Activity
I. Gritsenko (Jerusalem, Israel) et al.

HLA

113. Association Studies of HLA Genes in Families with Linkage to Chromosome 6p
J. Freymann (Bonn, Germany) et al.

114. Association between Schizophrenia and HLA Class 11 Markers among the Chinese
V. Nimgaonkar (Pittsburgh, PA, USA) et al.

115. Schizophrenia and HLA: No Association with PCR-SSOP Typed Classical Loci in a Large Irish Familial Sample
Z. Hawi (Dublin, Ireland) et al.

PAX Genes

116. Association Analysis of a CA-Repeat Polymorphism within the Promotor B-Region of a Human PAX-6 Gene in Alcoholism
J. Samochomdec (Szczecin, Poland/Berlin, Germany) et al.

117. Association Analysis of the Dinucleotide Repeat Polymorphism in the Regulatory Region of the Human PAX-6 Gene with Psychiatric Disorders
O. Okladnova (Würzburg, Germany) et al.

Miscellaneous Candidate Gene Studies

118. Heritable Polymorphisms in the Dopamine and Serotonin Receptors in Schizophrenic Patients and Healthy Controls
R. Kaiser (Berlin, Germany) et al.

119. Two Novel Variants in the Dopa Decarboxylase Gene: Genetic Fine Mapping and Preliminary Association with Bipolar Affective Disorder
A.D. Borglum (Aarhus, Denmark) et al.

120. Pharmacology of Naturally Occurring Variants of the Human Noradrenaline Transporter
F. Runkel (Bonn, Germany) et al.

121. Systematic Screening for Mutations in the Human NMDAR1 Gene in Patients with Schizophrenia
S. Paus (Bonn, Germany) et al.

122. Steroid Receptors/Co-Receptors and Schizophrenia: An Association Study
R. Joober (Verdun, Canada) et al.

123. Association Study of Brain-Derived Neurotrophic Factor (BDNF) Polymorphism in Schizophrenia
M.O. Krebs (Paris, France) et al.

124. An Association Study between Neuroleptic-Resistant Schizophrenia and Several DNA Markers
S. Peddni (Milano, Italy) et al.

125. Association Study of ldiopathic Primary Generalized Epilepsy (IGE)
P. Asherson (London, UK) et al.

126. Molecular Genotypes of Dopamine and Serotonin Metabolism-Related Genes in Major Depression
C. Cruz (Mexico-Xochimilco, Mexico) et al.

127. Mental Disorders and Criminal Behavior: A Genetic Approach
M. Verga (Milano, Italy) et al.

128. Identifying Candidate Genes in Narcolepsy: The Mainz Family Study
N. Dahmen (Mainz, Germany) et al.

129. An Association Study of 5-HT2A Receptor, Serotonin Transporter, and Tryptophan Hydroxylase Gene Polymorphisms in Major Depression
L. Du (Ottawa, Canada) et al.

130. Association between Social Adjustment and Candidate Gene Polymorphisms in Remitted Bipolar and Unipolar Patients
S. Blairy (Brussels, Belgium) et al.

131. Angiotensin Converting Enzyme Polymorphism in Schizophrenia and Major Affective Disorder: Population and Family-Based Association Studies
R.H. Segman (Jerusalem, Israel) et al.

132. An Association Study between the Al and A2A Adenosine Receptor Genes and Panic Disorder in a Japanese Population
Y. lnada (Osaka, Japan) et al.

133. Genetic Studies in Eating Disorders
D. Di Bella (Milano, Italy) et al.

134. Sex Differences in Pathological Gambling: Genetic Contribution
A. Ibahez (Madrid, Spain) et al.

135. Association of Endopeptdase (CDIONE) Dinucleofide Repeat Polymorphism with Anxiety, Depression, and P300 Amplitude
J.P. Johnson (Loma Linda, CA, USA) et al.

136. Association/Linkage Disequilibhum of G-olfa in 59 Families with Schizophrenic Index Patients in the Presence of Linkage
D.B. Wildenauer (Bonn, Germany) et al.

137. Associations between the Gamma-Interferon Gene (IFNG3), Asthenia and Obesity
J. MacMurray (Loma Linda, CA, USA) et al.

138. No lnteraction of GABAA Alpha-1 Subunit and Dopamine Receptor D4 GeneS'n Symptomatology of Major Psychoses
A. Serretti (Milano, Italy) et al.

139. Distribution of a Common Polymorphism of the Methylenetetrahydrofolate Reductase Gene in Patients with Schizophrenia or Affective Disorders
C. Virgos (Reus, Spain) et al.

140. Comparative Sequencing and Association Studies of Proneurotensin in Schizophrenia and Bipolar Disorder
J. Austin (Cardiff, UK) et al.

141. Polymorphism Screening of the Human Type 1 Sigma (a) Receptor (a Candidate Gene for Schizophrenia) Using a Modified Dideoxyfingerpointing Technique
G. Spurlock (Cardiff, UK) et al.

142. Analysis of TRK C RNA Levels in Psychiatric Post-Mortem Brains
T.A. Bayer (Bonn, Germany) et al.

143. GABA, Receptor Subunit Genes and Affective Disorders: An Association Study in the Bulgarian Population
R. Kaneva (Sofia, Bulgada) et al.

VIII. Pharmacogenetics

144. Affective Symptoms and Family History of Affective Disorder in Patients with Tardive Dyskinesia
T.G. Schulze (Bonn, Germany) et al.

145. Familial Occurrence of Tardive Dyskinesia
D.J. Müller (Bonn, Germany) et al.

146. Genetic Analysis of CYP2D6 Locus of Hong Kong Chinese Psychiatric Patients
M.M. Garcia-Barcelo (Hong Kong, China) et al.

147. The Histaminergic System in Schizophrenia and Drug Response
D. Mancama (London, UK) et al.

148. Genomic Characterization of Genes Encoding Human Myo-Inositol Monophosphatase Enzymes
G. Sjoholt (Bergen, Norway) et al.

149. Genomic Structure and Sequence Analysis of a Human lnositol Polyphosphate 1-Phosphatase Gene (INPP1)
R. Lovlie (Bergen, Norway) et al.

IX. Schizophrenia

Linkage Studies

150. A Potential Susceptibility Locus on Chromosome 10p14-pl 1 in 72 Families with Schizophrenia
S.G. Schwab (Bonn, Germany) et al.

151. A Potential Susceptibility Locus for Schizophrenia on 22q12-q13: Re-Evaluaton in 72 Families
J. Hallmayer (Mt. Claremont, Australia) et al.

152. No Evidence for Linkage of Schizophrenia with the Glutamate GluR5 and GluR6 Receptor Genes in Taiwanese Pedigrees
M.W. Lin (Taipei, Taiwan) et al.

153. An Affected Sib-Pair Study for Schizophrenia on the X-Chromosome
N. Norton (Cardiff, UK) et al.

154. Prospects of a Genome-Wide Linkage Analysis in Periodic Catatonia
G. Stöber (Würzburg, Germany) et al.

155. Weak Evidence of Linkage väth Markers on Chromosome 6p in Taiwanese Schizophrenic Families
H.G. Hwu (Taipei, Taiwan) et al.

156. A Systematic Search for Genes Determining Age of Onset in Schizophrenia
A.G. Cardno (Cardiff, UK) et al.

157. Searching for Candidate Genes for Schizophrenia in Chromosome 6p22-p23: Isolation of a BAC Contg Spanning 3.5 Megabas
G.N. Eckstein (Bonn, Germany) et al.

Chromosome Abnormalities

158. Familial Schizophrenia with Pericentric Inversion of Chromosome 9: A Case Report
K.B. Lee (Tokyo, Japan) et al.

159. Chromosomal Abnormalities in 254 Schizophrenics
H. Kunugi (Tokyo, Japan) et al.

160. Folate-Sensitive Fragile Sites in Schizophrenia and Bipolar Disorder: Candidate Regions for Susceptibility Loci?
J.J.A. Holden (Kingston, Canada) et al.

161. Identification of Two Genes Disrupted by the Chromosome One Breakpoint of a Balanced Translocation Linked to Schizophrenia
J.K. Millar (Edinburgh, UK) et al.

162. Mapping the Breakpoints in a Family with Inv 18(pl 1.3;q21. 1) and Schizophrenia
R.M. Hampson (Edinburgh, UK) et al.

163. Thirty-Year Follow-up of a Family Showing Association of Schizophrenia with a Balanced Translocation t(1: 1 1)(q42. 1,q 1 4.3)
D. Blackwood (Edinburgh, UK) et al.

Brain Morphology

164. MRI Brain Morphometry in Families with Schizophrenia, Sporadic Schizophrenia, and Controls
R. Tepest (Bonn, Germany) et al.

165. Brain Abnormalities in Relatives of Schizophrenic Patients ldentified by Structural Magnetic Resonance Imaging
M.T. Tsuang (Boston, MA, USA) et al.

166. Deviations in Brain Structure as Pointers to the Role of Asymmetry and Sex in the Genetics of Schizophrenia
T.J. Crow (Oxford, UK) et al.

167. A Case of Corpus Callosum Agenesia in a Psychotic Patent
N.B. Santos (Amadora, Portugal)

Triplet Repeats and Anticipation

168. Anticipation and Imprinting in Spanish Families with Schizophrenia
J. Valero (Reus, Spain) et al.

169. Screening for Expanded CAG/CTG Repeats in an Association Study Using 7,6a and ERDA 1
C.A. Guy et al. (Cardiff, UK) et al.

170. CAG Repeat Expansion in Parent-Offspring Pairs of Schizophrenic Patents
L. Martorell (Reus, Spain) et al.

171. Early Development in Schizophrenia: Relationship with Trinucleotide Repeats
A.K. Ayton (Hull, UK) et al.

Other Studies of Schizophrenia

172. Schizophrenia and Mitochondrial DNA: Association Studies
K. Gentry and V.L. Nimgaonkar (Pittsburgh, PA, USA)

173. A New Susceptibility Gene in Patients with Schizophrenia?
M. Gölge (Bremen, Germany) et al.

174. Apolipoprotein E Genotype in Chronically Institutionalized Geriatric Schizophrenic Patients in a Chinese Population
L.Y. Chow (Hong Kong, China) et al.

175. Neurological Soft Signs in Schizophrenic Twins
M. Weisbrod (Heidelberg, Germany) et al.

176. Cancelled

177. Dermatoglyphic Analysis in Bipolar Affective Disorder and Schizophrenia: "Continuum of Psychosis' Hypothesis corroborated?
N. Jelovac (Solin, Croatia) et al.

178. Informative MorphoGenetic Variants as Markers in Schizophrenia
M. Trixler (Pécs, Hungary) et al.

179. Heritability of Negative Signs in Families of Patients with Schizophrenia
E.A. Fedorova (Moscow, Russia) et al.

180. Genetic Determination of Some Parameters of Attention in the Families of Schizophrenics
T.D. Savina (Moscow, Russia) et al.

181. The Rigidity of Mental Processes in the Structure of Functional and Morphofunctional Systems Predispositioning to Schizophrenia
V.A. Odova (Moscow, Russia) et al.

182. Premorbid Social Functioning and Premorbid Personality in Schizophrenics and Same-Sex, Unaffected Siblings
U. Willinger (Vienna, Austria) et al.

183. Exploring Latent Dimensions of Cognitive Impairment in Schizophrenic Families
M.V. Alfimova and V.l. Trubnikov (Moscow, Russia)

184. Kraepelin's Diagnostic Criteria and their Application to Psychiatric Genetics
M. Ast (Glen Oaks, NY, USA) and S.L. Wieder (Rock Hill, NY, USA)

185. Statistical Identification of Symptomatologic Pattems of Schizophrenia by Factor Analysis
H. Krauss (Bonn, Germany) et al.

186. Cancelled

187. Reliability and Validity of the Premorbid Adjustment Scale in a German Sample of Schizophrenic and Schizoaffective Patients
H. Krauss (Bonn, Germany) et al.

188. Schizophrenia, Natural Selection, and Appendicitis
H. Ewald (Aarhus, Denmark) et al.

189. Hispanic Families with Simple or Multiple Schizophrenic Members: Characteristics of the Costa Rican Sample
C. Pal-Hegedus (San Jose, Costa Rica) et al.

190. Role of Hereditary Factors in the Genesis of Psychotic Forms of Psycho-Sexual Disorders of Schizophrenic Origin
K.G. Danielyan and A.K. Danielyan (Yerevan, Armenia)

191. Red Cell Membrane Fatty Acids, Cytosolic Phospholipase-A2, and Schizophrenia
A.B. Dohs (Edinburgh, UK) et al.

X. Affective Disorder

Linkage Studies


192. Chromosome 4 and Bipolar Disorder: A Screen for Disease Loci in the Irish Population
V. Murphy (Dublin, Ireland) et al.

193. Supportive Evidence for a Bipolar Susceptibility Gene on Chromosome 4q35
M.G. Mclnnis (Baltimore, MD, USA) et al.

194. No Linkage Found between Chromosome 1 1 p15.5 Markers and Manic-Depressive Illness
A. McQuillin (London, UK) et al.

195. Significant Linkage between Bipolar Affective Disorder and Chromosome 12q24
H. Ewald (Aarhus, Denmark) et al.

196. Genetic Analysis of the 12q Candidate Region for Bipolar Disorder
G.R. Verheyen (Antwerp, Belgium) et al.

197, A Search for a Shared Segment of Chromosome 18 in Patients with Bipolar Affective Disorder from the Faeroe Islands
H. Ewald (Aarhus, Denmark) et al.

198. The Welcome Trust UK-Irish Bipolar Sib-Pair Study: Chromosome 21
P. Benett (Birmingham, UK) et al. for the Welcome Trust Bipolar Group

199. Bipolar Affective Disorder Susceptibility Loci on Chromosomes 5 and 21: Heterogeneity in a Homogeneous Population in Quebec
E. Shink (Ste-Foy, Canada) et al.

Chromosome Abnormalities

200. A Study of Numerical Sex Chromosome Abnormalities in Patients with Recurrent Major Depressive Disorders
C. Chateiain (Clermont-Ferrand, France) et al.

Triplet Repeats and Anticipation

201. Evidence for Anticipation in Familial Bipolar Disorder
R.J. Olds (Dunedin, New Zealand) et ai.

202. A Study of Anticipation and Parent-of-Origin Effects in a Large Bipolar Family Showing Linkage to Chromosome 4
A.D. Jackson (Edinburgh, UK) et al.

203. No Evidence of Proteins Containing Long Polyglutamine Tracts in the Pathogenesis of Bipolar Disorder
G. Turecki (Montreal, Canada) et al.

204. Detection of Expansion Regions in Bipolar Families
C.N. Pato (Buffalo, NY, USA) et al.

205. Functional Polymorphic Triplet Repeats in Psychiatric Disorders: An Association Study
R. Kato (Zurich, Switzerland) et al.

206. Genetic Anticipation in Portuguese Families with Bipolar Affective Disorder
A. Macedo (Coimbra, Portugal) et al.

207. Association Study of Seasonal Affective Disorder
C. Johansson (Stockholm, Sweden) et al.

Other Studies of Affective Disorder

208. An Allelic Association Study of Candidate Genes in the Chromosome 21 q22.3 Region Implicated in Bipolar Affective Disorder
A. McQuillin (London, UK) et al.

209. Molecular Genetic Approaches to Puerperal Psychosis
I.R. Jones (Birmingham, UK) et al.

210. Establishment of an Andalusian Family Collection for Bipolar Affective Disorder
G. Orozco (Malaga, Spain) et al.

21 1. Bipolar Disorder and Sensation Seeking
F. McCandless (Birmingham, UK) et al.

212. Preliminary Results from the Otago Familial Bipolar Genetic Study
A.E.S. Walsh (Dunedin, New Zealand) et al.

213. Genetic Pattems in Mixed Bipolar Disorder
J. W'ilcox (EI Paso, TX, USA)

214. Welcome Trust UK/Ihsh Bipolar Sib-Pair Study: Clinical Similarities in Siblings
E. O'Mahony (Dublin, Ireland) et al. for the Welcome Trust UK/Irish Bipolar Sib Pair Study Group

215. Haptoglobin Genetic Variation and Risk for Major Depression with Melancholia
B. Arias (Barcelona, Spain) et al.

XI. Obsessive-Compulsive Disorder

216. A Mendelian Form of Obsessive-Compulsive Disorder Derived from Symptom-Based Factors
J.P. Alsobrook 11 (New Haven, CT, USA) et al.

7. A Family Study of Childhood Obsessive-Compulsive Disorder
Khanna (Bangalore, India) et al.

218. TPQ Profiles of OCD Families, GTS Families, and Normal Controls
L. Lev-Ad and A.H. Zohar (Jerusalem, Israel)

XII. Autism

219. Horizontal versus Vertical Inheritance in Autism: Autistic Features in Fathers of Autistic Children
O. Weiffenbach (Frankfurt, Germany) et al.

220. The Broader Phenotype of Autism: Comparison between Siblings of Individuals wb Autism and Individuals with Other Diagnoses
N. Yirmiya (Jerusalem, Israel) et al.

221. Concepts and Findings of Clinical Genetic Studies of Autism in Germany
F. Poustka (Frankfurt, Germany) et al.

222. Case Report: Autistic Disorder, Chromosomal Abnormality 46,XX Duplication(4)pl 2-pl 3, and Charge Association
P. Vroegop and M. Sabaratnam (London, UK)

223. Model for the Genetics of Autism and the Related Pervasive Developmental Disorders Combining a Maternal Effect with Susceptibility Factors in the Fetus
J.J.A. Holden (Kingston, Canada) et al.

XIII. Child Psychiatric Disorders

224. Norepinephrine Genes, ADHD, and Learning Disorders
D. Comings (Duarte, CA, USA) et al.

225. Association Study of DSM-IV Attention Deficit Hyperactivity Disorder (ADHD) and Monoamine Pathway Genes
P. Asherson (London, UK) et al.

226. Neutral Endopeptidase EC 3.4.24.11 (NEP) as a Marker of an Internalizing Subgroup of Conduct Disorders
M. Huss (Berlin, Germany) et al.

227. Infant Hyperactivity Shows High Heritability
T.S. Price (London, UK) et al.

228. Androgen Receptor Gene, Conduct, and Oppositional Defiant Disorder
D. Comings (Duarte, CA, USA) et al.

229. Cognitive Function and Behavioral Problems in Children and Adolescents with Spinal Muscular Atrophy
A. von Gontard (Cologne, Germany) et al.

230. Serotonergic System in Children and Adolescent Affected by Depressive Disorders: Biological and Genetic Aspects
M. Nobile (Bosisio Parini, Italy) et al.

Alcoholism

231. Comorbid Habitual Smoking and Alcohol Dependence: A Genomic Survey
L.J. Bierut (St. Louis, MO, USA) et al.

232. Evaluaton of the Respective Role of Depression and Alcoholism in the Familial History of Alcoholic Subjects, with or without Comorbid Depression
F. Limosin (Colombes, France)

233. CytoGenetic Abnormalities and Alcoholism
O. Mors (Aarhus, Denmark) et al.

234. Structural Decomposition of Genetic Diversity in Families with Alcohol Dependence
H.H. Stassen (Zurich, Switzerland) et al.

XV. Mental Retardation

235. Genotype-Phenotype Relationship in Female Pre- and Full Mutation Fra-X Carriers
P. Franke (Bonn, Germany) et al.

236. Behavioral Phenotype of the Fragile-X-Syndrome
A. von Gontard (Cologne, Germany) et al.

237. Identification of Microaberrations at Subtelomeric Chromosomal Regions in Children with Mental Retardation
S.G. Vorsanova (Moscow, Russia) et al.

238. A Complex Re-Arrangement of Karyotype Involving Chromosomes 2 and 1 1 Detected in a Patient-with the Dual Diagnosis of Schizophrenia and Mild Learning Disability
W.J. Muir (Edinburgh, UK) et al.

239. The Di GeorgeNelo-Cardio-Facial Region of Chromosome 22 in Patients with Dual Diagnosis of Psychosis and Learning Disability
W.J. Muir (Edinburgh, UK) et al.

240. Genomic Structure of the Human CDX-4 Gene: A Potential Candidate for the FG Syndrome
P. Chiaroni (Marseille, France) et al.

241. High Heritability for Language Delay in Infancy
S. Purcell (London, UK) et al.

XVI. Alzheimer's Disease

242. Gender Differences in APOE-Associated Brain Weights of Alzheimers Disease Cases
H. Blake (Duarte, CA, USA) et al.

243. Variation at the Apolipoprotein E Locus and Risk for Alzheimers Disease: Cladistic Analysis
C.L. Lendon (Birmingham, UK/St. Louis, MO, USA) et al.

244. Prediction of APOE Genotype by Phenotype in Alzheimer's Disease
R.D. Todd (St. Louis, MO, USA) et al.

245. Unexpected Spectrum of Disease-Causing Mutations in a Clinical Sample of Patients with Presenile Dementia
U. Finckh (Hamburg, Germany) et al.

246. PCR-RFLP Analysis of Genes Involved in Amyloid Precursor Protein (APP) Processing: An Association Study to Elucidate the Implications for Alzheimers Disease
M. Bagli (Bonn, Germany) et al.

247. The Contribution of an lntronic Polymorphism of the Presenilin-1 Gene to the Familial Aggregation of Alzheimers Disease
A. Papassotiropoulos (Bonn, Germany) et al.

248. Variable Number Tandem Repeat (VNTR) Polymorphism of the Interleukin-6 Gene in Alzheimers Disease: An Association Study
A. Papassotiropoulos (Bonn, Germany) et al.

249. No Association between Two Promotor Polymorphisms of the Human N-Acetyltransferase Gene (AA-NAT) and Alzheimers Disease
J.T.P. Birkett (London, UK) et al.

250. Some Aspects of the Etiology of the Dementia of Alzheimers Type
N.1. Voscresenskaya (Moscow, Russia) et al.



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